Carlos V. Grijalva

Carlos V. Grijalva
OccupationsPhysiological psychologist and academic
Academic background
EducationB.A.
M.A.
Ph.D.
Alma materUniversity of Arizona
Arizona State University
Academic work
InstitutionsUniversity of California, Los Angeles

Carlos V. Grijalva is a physiological psychologist and academic. He is an emeritus professor of Psychology and Neuroscience and a member of the Brain Research Institute at the University of California, Los Angeles. His work has conducted research on the psychobiology of stress, behavior, and disease in animal models, with a focus on neural and behavioral mechanisms of feeding and gastrointestinal function.

Education

Grijalva received a B.A. degree from the University of Arizona in 1972. Later, he completed his M.A. from Arizona State University in 1974 and his Ph.D. from the same university in 1977.[1]

Career

Grijalva joined the University of California, Los Angeles (UCLA) as a research associate from 1980 to 1981. He assumed the role of assistant professor in 1982 and later became an associate professor in 1986. In 1993, he was appointed professor at UCLA, a position he held until his retirement in 2017. His administrative roles at UCLA included working as interim chair of the César Chávez Center for Interdisciplinary Instruction in Chicana and Chicano Studies in 1994[2] and as associate dean in the Division of Honors and Undergraduate Programs from 1991 to 1996. Additionally, from 2007 to 2017[3] and again from 2019 to 2020, he was associate dean of the UCLA Graduate Division.[4][1] He is an emeritus professor of Psychology and Neuroscience at UCLA,[5] and is a member of the university's Brain Research Institute.[6]

Research

Grijalva's research has examined the neural mechanisms connecting feeding behavior, stress, and digestive function, with a focus on the hypothalamus and related brain regions. Through animal studies, he showed that damage to specific areas of the hypothalamus could cause gastric ulcers[7] and other disturbances in digestion, demonstrating a link between brain activity and gastrointestinal processes.[8] His experiments indicated that factors such as diet[9] and insulin levels influence the development of gastric lesions.[10] He identified the ventromedial hypothalamus as an inhibitory center for gastric activity,[11] while the medial amygdala appeared to enhance acid secretion.[12]

Grijalva also found that hormone responses, such as gastrin release, were centrally mediated[13] and that the hypothalamus and limbic system contribute to the cephalic phase of digestion,[14] which is activated by sensory cues.[15] In addition to his work on gastric function, he investigated dopaminergic pathways and observed changes in neurotransmitter levels following neural stimulation or damage.[16] In studies related to stress and eating disorders, he demonstrated that thermal treatment increased survival in animal models of activity-based anorexia,[17] showing that exposure to heat shortly before a moribund state improved both the likelihood and duration of survival.[18]

Awards

  • 2005 – Distinguished Teaching Award, UCLA[19]
  • 2012 – Diversity, Equity and Inclusion Award, UCLA Academic Senate[20]

Selected articles

  • Lindholm, Ernest; Shumway, Gary S.; Grijalva, Carlos V.; Schallert, Timothy; Ruppel, Michael (1975). "Gastric pathology produced by hypothalamic lesions in rats". Physiology & Behavior. 14 (2): 165–169. doi:10.1016/0031-9384(75)90161-4.
  • Grijalva, Carlos V.; Lindholm, Ernest; Novin, Donald (1980). "Physiological and morphological changes in the gastrointestinal tract induced by hypothalamic intervention: An overview". Brain Research Bulletin. 5 (Supplement 1): 19–31. doi:10.1016/0361-9230(80)90299-3. PMID 6992945.
  • Shimizu, Nobuaki; Oomura, Yutaka; Novin, Donald; Grijalva, Carlos V.; Cooper, Peter H. (1983). "Functional correlations between lateral hypothalamic glucose-sensitive neurons and hepatic portal glucose-sensitive units in rat". Brain Research. 265 (1): 49–54. doi:10.1016/0006-8993(83)91332-X.
  • Bermúdez-Rattoni, Federico; Grijalva, Carlos V.; Kiefer, Stephen W.; Garcia, John (1986). "Flavor-illness aversions: The role of the amygdala in the acquisition of taste-potentiated odor aversions". Physiology & Behavior. 38 (4): 503–508. doi:10.1016/0031-9384(86)90417-8. PMID 3823162.
  • Grijalva, Carlos V; Novin, Donald (1990). "The role of the hypothalamus and dorsal vagal complex in gastrointestinal function and pathophysiology". Annals of the New York Academy of Sciences. 597 (1): 207–222. Bibcode:1990NYASA.597..207G. doi:10.1111/j.1749-6632.1990.tb16169.x. PMID 2167033.

References

  1. ^ a b "UCLA Graduate Division" (PDF). UCLA Life Sciences Psychology. Retrieved November 17, 2025.
  2. ^ "UCLA Picks Interim Head for Chicano Studies : Education: Some activists criticize appointment of administrator who helped negotiate end to hunger strike". Los Angeles Times.
  3. ^ "Two professors appointed associate deans in UCLA's Graduate Division". University of California Los Angeles.
  4. ^ "To: Deans, Directors, Department Chairs, and Faculty" (PDF). University of California Los Angeles.
  5. ^ "Carlos V. Grijalva". UCLA Department of Psychology. 12 August 2021. Retrieved October 23, 2025.
  6. ^ "Carlos Grijalva, Ph.D." UCLA Brain Research Institute. Retrieved October 23, 2025.
  7. ^ Ossenkopp, Klaus-Peter; Wiener, Neil I.; Nobrega, José N. (1980). "Ventromedial hypothalamic lesions and stomach ulcers: Reduction by non-nutritive bulk ingested in the post lesion period". Physiology & Behavior. 24 (6): 1125–1131. doi:10.1016/0031-9384(80)90058-X. PMID 6251489.
  8. ^ Weiner, H. (1996). "Use of animal models in peptic ulcer disease". Psychosomatic Medicine. 58 (6): 524–545. doi:10.1097/00006842-199611000-00002. PMID 8948002.
  9. ^ Schulkin, Jay (1988). "The effects of preoperative ingestive events on feeding and drinking behavior following brain damage". Psychobiology. 16 (3): 185–195. doi:10.3758/BF03327306.
  10. ^ Kanarek, Robin B.; Konecky, Mark S. (1985). "Preoperative experience with insulin enhances glucoprivic feeding in rats with lateral hypothalamic lesions". Physiology & Behavior. 34 (6): 987–994. doi:10.1016/0031-9384(85)90025-3. PMID 3903796.
  11. ^ Watanabe, K.; Yano, S.; Lin, W. C. (1987). "Stimulatory effect of pentobarbital and some anesthetics on gastric secretion in the continuously perfused stomach in rats under urethane anesthesia". Japanese Journal of Pharmacology. 44 (1): 63–69. doi:10.1254/jjp.44.63. PMID 2887684.
  12. ^ Kim, M. S.; Jo, Y. H.; Yoon, S. H.; Hahn, S. J.; Rhie, D. J.; Kim, C. C.; Choi, H. (1990). "Electrical stimulation of the medial amygdala facilitates gastric acid secretion in conscious rats". Brain Research. 524 (2): 208–212. doi:10.1016/0006-8993(90)90692-5. PMID 2292003.
  13. ^ Martinez, Vicente; Taché, Yvette (2000). "Bombesin and the brain-gut axis". Peptides. 21 (11): 1617–1625. doi:10.1016/S0196-9781(00)00293-X.
  14. ^ Puurunen, J (1983). "Central nervous system effects of arachidonic acid, PGE2, PGF2 alpha, PGD2 and PGI2 on gastric secretion in the rat". British Journal of Pharmacology. 80 (2): 255–262. doi:10.1111/j.1476-5381.1983.tb10028.x. PMC 2045023. PMID 6360279.
  15. ^ Puurunen, Juhani (1983). "Inhibition of gastric acid secretion by intracerebroventricularly administered prostaglandin E2 in anaesthetized rats". British Journal of Pharmacology. 78 (1): 131–135. doi:10.1111/j.1476-5381.1983.tb09372.x. PMC 2044780. PMID 6337659.
  16. ^ Wang, Ke; Yuan, Kexin; Li, Runting; Lin, Fa; Chen, Yu; Yang, Jun; Han, Heze; Li, Tu; Jia, Yitong; Zhou, Yunfan; Zhang, Haibin; Li, Ruinan; Li, Zhipeng; Zhao, Yahui; Hao, Qiang; Chen, Xiaolin; Zhao, Yuanli (2023). "Prediction of stress-related gastrointestinal bleeding in patients with aneurysmal subarachnoid hemorrhage using caudate Hounsfield unit value in ASPECT score". Frontiers in Neurology. 14 1237310. doi:10.3389/fneur.2023.1237310. PMID 37780721.
  17. ^ Södersten, Per; Bergh, Cecilia; Ammar, Ahmed (2003). "Anorexia nervosa: towards a neurobiologically based therapy". European Journal of Pharmacology. 480 (1–3): 67–74. doi:10.1016/j.ejphar.2003.08.093. PMID 14623351.
  18. ^ Hillebrand, Jacquelien J G; de Rijke, Corine E; Brakkee, Jan H; Kas, Martien J H; Adan, Roger A H (2005). "Voluntary access to a warm plate reduces hyperactivity in activity-based anorexia". Physiology & Behavior. 85 (2): 151–157. doi:10.1016/j.physbeh.2005.03.017. PMID 15924912.
  19. ^ "Psychology Department Faculty Awards". ULCA. Retrieved 6 January 2026.
  20. ^ "Campus Announcement: Search for New Associate Dean in the Graduate Division" (PDF). Retrieved 6 January 2026.
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